Module Code - Title:
BM4214
-
THERAPEUTICS AND TARGETING CELLULAR COMMUNICATION
Year Last Offered:
N/A
Hours Per Week:
Grading Type:
N
Prerequisite Modules:
BY4203
Rationale and Purpose of the Module:
This module serves as a continuation of the "Cellular Pathways and Pathophysiology in Health and Disease" module, delving deeper into advanced concepts and emerging topics in the targeting of molecules for the treatment of disease. Building upon the knowledge acquired in the previous module, students will explore cutting-edge knowledge in cellular communication, with a focus on understanding the complexities of signalling networks, their implications in human health and disease and the approaches to targeting of cellular communication for disease treatment. This module has been specifically designed to provide students with the knowledge and skills to support their progression into years 3 and 4 of the case-based KHI curriculum.
Syllabus:
The following is indicative of the content to be covered in this syllabus:
• Introduction to Targeted Therapies/ Revision of cellular pathways • Cellular communication dynamics • Targeting phosphorylation: design and development of kinase inhibitors • Blocking interactions: Monoclonal antibodies and biologics • Editing pathways: Genetic engineering and gene therapy applications • Precision targeting: Personalized medicine approaches.
Learning Outcomes:
Cognitive (Knowledge, Understanding, Application, Analysis, Evaluation, Synthesis)
On successful completion of this module, students will be able to:
• Describe the molecular mechanisms underpinning cellular communication in health and disease;
• Recognise the importance of targeting cellular communication in disease treatment;
• Outline the mechanisms by which drugs are delivered to target cellular communication;
• Describe genetic engineering and outline the basis behind gene therapy.
Affective (Attitudes and Values)
On successful completion of this module, students will be able to:
• Reflect on the integration of scientific knowledge within clinical practice
• Reflect on how scientific research approaches are advancing personalised medicine and disease monitoring
Psychomotor (Physical Skills)
On successful completion of this module, students will be able to:
N/A
How the Module will be Taught and what will be the Learning Experiences of the Students:
The curriculum has been designed to foster enquiry and self-directed learning among students, by avoiding overload of factual learning and ensuring a supportive learning environment.
This module will be taught via lecture, labs and tutorial using a case study approach to enable students to confidently apply therapeutic and pharmacological knowledge within a clinical environment. Outside this formal contact the student will be encouraged to develop skills in acquiring information as individual learners as well as working in group learning teams.
This module addresses the graduate attributes of curious (providing knowledge and critical thinking), agile (developing the independent and adaptive learner), courageous (robust), and articulate (collaborative).
The ethos across the curriculum is to ensure research led teaching Lecture content will be constantly updated to incorporate new findings in the field of cellular communication.
Research Findings Incorporated in to the Syllabus (If Relevant):
Prime Texts:
George Plopper, PhD; Diana Bebek Ivankovic (2021)
Principles of Cell Biology, Third Edition
, Jones and Bartlett Learning
Jocelyn E. Krebs, PhD; Elliott S. Goldstein, PhD; Stephen T. Kilpatrick, PhD (2018)
Lewin's GENES XII
Twelfth Edition
, Jones and Bartlett Learning
George Plopper, PhD; David Sharp, PhD; Eric Sikorski, PhD (2015)
Lewin's CELLS
Third Edition
, Jones and Bartlett Learning
Other Relevant Texts:
Programme(s) in which this Module is Offered:
BMMESUUFA - BACHELOR OF MEDICINE BACHELOR OF SURGERY
Semester(s) Module is Offered:
Spring
Module Leader:
Patrick.Kiely@ul.ie