Integrative Physiology is the study of key mechanisms and regulatory functions underpinning physiological processes at all biological levels ranging from the molecular and cellular level to tissue and organs. In this module we will introduce students to the basic concepts and principles of integrative physiology with a focus on neuronal, neuroendocrine, and endocrine control of organ systems. On completion of the module, students will be able to: demonstrate a knowledge of the structure and function of major human physiological systems. Additionally, the influence and relationship between various human physiological conditions will be considered.

This module will examine the structure and function of the major human physiological systems. The nervous system, from the cellular level to neural circuits and the processing and translation of information to activate or maintain homeostasis of other organ systems through nerve impulses or hormonal control. The endocrine system, together with the nervous system performing neuroendocrine signaling. Key organ systems under control of neuronal, endocrine, and neuroendocrine signaling are discussed with a focus on the male and female reproductive systems, including spermatogenesis and the endocrine regulation of puberty and sexual function. Further, the physiology of the female reproductive cycle, the establishment of pregnancy as well as the regulation of parturition and lactation. The physiology of other systems under the control of neuronal, endocrine, and neuroendocrine signaling such as the musculoskeletal system are investigated, including the control of contraction/relaxation of skeletal muscle as well as the synthesis and remodeling of bone, and the physiology of the cardiovascular system, the cardiac cycle, neuroendocrine regulation of cardiac output, and blood pressure.

Describe the functions of the major physiological systems of the human body and how they are controlled by nervous and endocrine signaling, e.g., the cardiovascular system, musculoskeletal, and reproductive system. Compare and contrast the role of a range of human physiological processes associated with homeostasis. Describe the processes associated with positive and negative feedback systems in human physiology. Evaluate the influence and relationship between various human physiological conditions and external factors. Identify the factors that influence human physiological systems and the ways this is controlled. Students will develop an appreciation for the importance of integrating physiological systems, their significance in maintenance of homeostasis, information processing, and translation to physical and mental health, particularly as applies to endocrinology and neurology.

N/A

N/A

Teaching and learning will include such methods as, lectures, tutorials, discussions, group work, self-directed learning, recommended reading, reflection, seminars and workshops.