Module Code - Title:

BY4048 - ADVANCED CELL AND MOLECULAR BIOLOGY

Year Last Offered:

2025/6

Hours Per Week:

Lecture

2

Lab

2

Tutorial

0

Other

0

Private

6

Credits

6

Grading Type:

Prerequisite Modules:

Rationale and Purpose of the Module:

The module will examine cellular structures including the organelles, cytoskeleton, molecular motors and key cellular processes including trafficking, cell cycle, apoptosis events and motility. The module will present the genetics of model systems and how they are used to study development, differentiation and disease. The module will present new technologies in studying systems biology of organisms and how to extract meaningful data from large data sets. These technologies will include those used for the analysis of cell responses by confocal microscopy, flow cytometry, transcriptomics, metabolomics and proteomics. The module will use extensive reading of primary literature and reviews to embed the knowledge of techniques, capabilities and challenges in the area.

Syllabus:

The syllabus will include Cell structure; Cytoskeleton,Molecular motors and trafficking systems in cells, Cell motility, Cell cycle, Cell differentiation and development, Apoptosis Examining cellular structures, Profiling cells at a molecular level

Learning Outcomes:

Cognitive (Knowledge, Understanding, Application, Analysis, Evaluation, Synthesis)

Students will acquire a detailed knowledge of the internal structures of mammalian cells and their functions. The student will acquire knowledge of the methodologies used to study cell structures and multi-platform 'omics' analysis. Reading of primary literature will develop skills in critical thinking and enable students to evaluate current research experimental strategies and to interrogate data from these studies.

Affective (Attitudes and Values)

N/A

Psychomotor (Physical Skills)

N/A

How the Module will be Taught and what will be the Learning Experiences of the Students:

The module will be taught by lectures, laboratories and directed reading. A combination of computer and wet-lab experimentation will support the students learning, providing hands on experience in analysis of 'omics' data, and demonstrations and practicals on confocal microscopy, cell culture, apoptosis assays, and flow-cytometry. The module will incorporate a significant component of reading involving current primary literature, in this context research findings will be incorporated into the learning experience.

Research Findings Incorporated in to the Syllabus (If Relevant):

Prime Texts:

() This module will utilize primary literature as the main basis of acquisition of new knowledge. This will primarily be from journals such as Science, Nature, Nature Medicine, Cell, Nature Biotechnology, Nature Reviews series. ,

Other Relevant Texts:

Lodish, H. Berk, A., Kaiser, C.A., Krieger, M., Scott, M.P., Bretscher, A., Ploegh, H., Matsudaira, P. (2016) Molecular Cell Biology (Lodish, Molecular Cell Biology) 6th Edition , MacMillan, New York

Alberts, B., Bray,D., Hopkin, K., Johnson, A., Lewis, J., Raff, M Roberts, K., and Walter, P. (2014) Essential Cell Biology, 4th Edition , Garland Science, New York

Programme(s) in which this Module is Offered:

Semester(s) Module is Offered:

Spring

Module Leader:

george.barreto@ul.ie