This problem-based online learning module aims to discuss and interpret the structural and functional characteristics of eukaryotic cells with emphasis on the transduction of different forms of energy usable by organisms to carry out a biological function. The main aspects to be covered range from the origin of the cells to the greater degree of subcellular organization and functionality of eukaryotic cells. It focuses on the basic elements of regulatory systems, both by modulation of enzymatic activity and controlled proteogenesis/proteolysis, with special emphasis on cell signalling transduction. The basic concepts foreseen for the development of the module, as well as its integration, will provide students some tools to understand the cellular functioning and the relation with the composition and structure of eukaryotic cells, and investigate the importance of the biomolecules in the organization of cellular architecture and the normal development of its properties. It is important for the MSc student enrolled in this module to: - Understand the biological phenomena of cells and tissues - Correlate structure-function relationship with a given biological function - Interpret how to obtain and spend energy, as well as its control mechanisms in both physiological and pathological cellular environments.

This problem-based online learning module is divided into 5 topics: 1: Structure and function of biological membranes and membrane-initiated signalling 2: Nuclear activity, and gene expression 3: Endomembrane system: From protein synthesis to post-translational regulation of cell functions 4: Cell cycle: Regulation and cell division 5: Cellular metabolism and signalling through mitochondria

On completion of this online module students will be able to: 1. Recognize the morphological and functional properties of eukaryotic cells. 2. Identify the concept of cellular compartmentation for a controlled biological function. 2. Analyse the metabolic conditions in which energy is stored and how the cells utilize energy to carry out biological activities. 3. Identify the key molecules in the integration of metabolic pathways. 4. Understand the strategies that the cell uses for metabolic regulation. 5. Identify and describe the elements of signal transduction, as well as the types of cell signalling, taking into account their response at the metabolic level or gene regulation. 6. Demonstrate knowledge and understanding of the cellular functions under physiological and pathological states. 7. Develop writing and presentation skills and critical thinking towards the evaluation of data analysis and discussion of high impact papers.

On completion of this module students will be able to: Appreciate the value and importance of the knowledge to be obtained, particularly relative to the downstream implications for drug discovery and informing biological target and pharmacological treatments

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The module will be delivered online and taught by lectures, tutorials discussing case studies (problem-based learning) and directed reading. The module will incorporate a significant component of reading involving current primary literature, in this context research findings will be added into the learning experience.