Module Code - Title:

CG4003 - BIOPROCESS ENGINEERING 1

Year Last Offered:

2025/6

Hours Per Week:

Lecture

2

Lab

3

Tutorial

1

Other

0

Private

0

Credits

6

Grading Type:

Prerequisite Modules:

Rationale and Purpose of the Module:

Syllabus:

Overview of biochemical processes currently used on an industrial scale. Introduction to biochemical process design strategies for high value/low volume and low value/high volume products. Material and energy balances for bioprocessing operations. Aspects of mass transfer of importance in aerobic fermentations. Biochemical reaction kinetics for cell free enzyme, single cell, cellular agglomerate, and immobilised enzyme systems. Bioreactor design for ideal batch and ideal chemostat operations. Practical aspects of bioreactor operation and monitoring: sterilisation, asepsis, inoculation, rheology, aeration, agitation, instrumentation and sampling. Introduction to commercial-scale bioproduct separation and purification methods. Industrial biosafety.

Learning Outcomes:

Cognitive (Knowledge, Understanding, Application, Analysis, Evaluation, Synthesis)

1. Possess a knowledge of bioprocess design strategies for both low and high volume products. 2. Construct material and energy balance tables for bioprocessing operations. 3. Possess a knowledge of reaction kinetics of biochemical systems. 4. Demonstrate skills in the basic design, sizing, operation and optimisation of ideally-mixed bioreactors. 5. Demonstrate basic skills in the selection and sizing of bioproduct separation and purification systems. 6. Possess a detailed knowledge of industrial biosafety principles and the application thereof.

Affective (Attitudes and Values)

N/A

Psychomotor (Physical Skills)

1. Use an ODE solver computer package for the simulation of basic bioprocessing systems. 2. Show competence in the practical operation of basic bioreaction systems.

How the Module will be Taught and what will be the Learning Experiences of the Students:

Research Findings Incorporated in to the Syllabus (If Relevant):

Prime Texts:

M. L. Shuler, and F. Kargi (2001) Bioprocess Engineering: Basic Concepts, 2nd ed , Prentice Hall

R. G. Harrison, P. W. Todd, S. R. Rudge, and D. P. Petrides (2002) Bioseparations Science and Engineering , Oxford University Press

P.M. Doran (1995) Bioprocess Engineering Principles , Academic Press

G. Walsh (2007) Pharmaceutical Biotechnology: Concepts and Applications , Wiley

Other Relevant Texts:

H.S. Fogler (2006) Elements of Chemical Reaction Engineering, 4th ed , Prentice Hall

AIHA Biosafety Committee (1995) Biosafety Reference Manual , American Institute of Industrial Hygiene

N.S. Mosier and N.R. Ladisch (2009) Modern Biotechnology : Connecting Innovations in Microbiology and Biochemistry to Engineering Fundamentals , Wiley

Programme(s) in which this Module is Offered:

Semester(s) Module is Offered:

Module Leader:

Gavin.Walker@ul.ie