Module Code - Title:

CH4306 - ANALYTICAL CHEMISTRY 4

Year Last Offered:

2025/6

Hours Per Week:

Lecture

2

Lab

0

Tutorial

1

Other

0

Private

6

Credits

6

Grading Type:

N

Prerequisite Modules:

CH4305

CH4304

CH4303

Rationale and Purpose of the Module:

To review and extend the studentÆs existing knowledge and comprehension of fundamental spectroscopic techniques encountered in CH4303, CH4304 and CH4305; to provide the student with an-indepth working knowledge and comprehension of various advanced spectroscopic techniques; to emphasise the interpretation of spectral data in an integrated manner through the use of combined spectroscopic techniques; to highlight various applications of the techniques encountered; to encourage self-directed learning through the use of some recommended websites and software.

Syllabus:

Mass Spectrometry: Brief review of some basic principals; Fragmentation Patterns; Rearrangements; Interpretation of spectra; Hyphenated techniques. NMR Spectroscopy: 1-D 1HNMR: Review of some basic principals; Relaxation Processes; Homotopic, enantiotopic and diastereotopic systems; Nuclear Overhauser Effect (NOE); Second-Order Spectral Interpretation. 13C NMR: Theory; DEPT 13Cnmr; NOE, Quantitative13Cnmr; Interpretation of spectra. Solid State 13C nmr (brief). 2-D 1HNMR: COSY (1H-1H connectivity); NOESY, ROESY (through space 1H-1H proximity), HOSEY; HECTOR (1H - 13C connectivity); INADEQUATE (13C - 13C connectivity); TOCSY (1D and 2D); Interpretation of spectra. Structure elucidation using combined spectroscopic techniques (of those above). Laser Raman Spectroscopy: Theory; Comparison with FT-IR spectroscopy; Spectral interpretation of simple organic molecules and carbon allotropes (diamond, graphite and carbon nanotubes). Problem Sessions/Lab.

Learning Outcomes:

Cognitive (Knowledge, Understanding, Application, Analysis, Evaluation, Synthesis)

On successful completion of this Module and incorporating all spectroscopic techniques, the student should be able to 1. Define various spectroscopic terms as contained in syllabus above. 2. Describe the principals of both fundamental and advanced spectroscopic techniques, of the various spectroscopic modes encountered above. 3. Assign and interpret the spectral data provided to the structure of a known organic compound. 4. Predict and draw the expected spectrum for a given organic molecule. 5. Elucidate the structure of an unknown organic compound on the basis of both single mode spectroscopic data and combined spectroscopic data. 6. Apply the principals of Raman spectroscopy to intrepret the Raman spectrum of simple organic molecules.

Affective (Attitudes and Values)

N/A

Psychomotor (Physical Skills)

On successful completion of this Module the student should 1. Use recommended software/websites to enhance their knowledge and comprehension of the various spectroscopic techniques and their ability to interpret combined spectral data.

How the Module will be Taught and what will be the Learning Experiences of the Students:

This module will be taught over a 12 week period through a formal interactive lecturing mode (2 x 1 hour lectures; 1 hour tutorial per week); students will be given problems to solve in an ongoing way as a learning tool; operation of instrumentation will be demonstrated (initially). The Module will be assessed by the following means: End-of-semester written exam (90%); Mid-term assessment (10%). Lab sessions will not be assessed.

Research Findings Incorporated in to the Syllabus (If Relevant):

N/A

Prime Texts:

Balci M. (2005) Basic 1H-and C13-NMR Spectroscopy , Elsevier

Silverstein, R.M., Webster F.X. and Kiemle D.J. (2005) Spectrometric Identification of Organic Compounds , J. Wiley & Sons

Williams D. and Fleming I. (2008) Spectrometric Methods in Organic Chemistry , McGraw-Hill

Pavia D.L., Lampmann G.L. and Kriz G.S. (2008) Introduction to Spectroscopy , Hartcourt College Publishers

Schrader B. (1995) Infrared and Raman Spectroscopy , VCH Publishers Inc, NY.

Other Relevant Texts:

Solomons T.W.G. and Fryhle C.B. (2008) Organic Chemistry , John Wiley & Sons

Wehrli F.W. and Wirthlin T. (1980) Interpretation of C-13 NMR Spectra , Heyden

Programme(s) in which this Module is Offered:

Semester(s) Module is Offered:

Module Leader:

emmet.oreilly@ul.ie